The science behind Novacell

Cells and their evolution

The cell is the smallest unit with the basic properties of life, and all life is made up of cells. The process from a cell to complete living being begins with a single fertilized cell.

The cell undergoes a systematic process of development which begins with the cell splitting into two cells, the two cells split again to make four, the four split to make sixteen and this process repeats until there are many billions of cells. The human body contains 28 to 36 trillion cells!

Cells at the embryonic stage are known as totipotent stem cells, or more simply stem cells. They are generic in nature and do not yet reflect the characteristics that will go on to define specific organs. The process of change continues, and the cells are directed and coordinated to differentiate and so become specific organs.

This process of differentiation results in the formation of the heart, the liver the lungs, blood and skin and other organs and parts of the body.

How is cellular evolution directed?

But how is this process directed? How is it controlled?

The answer is that the development of the cell is controlled by information which is transmitted primarily through internal molecular and electromagnetic means.

Stem cells, pre-differentiation

Until recently scientists believed that DNA included all the information necessary for the development of life, but new research points to influences beyond DNA, to a field of information that controls and directs the DNA operating mode.

The development of the cell is controlled by information

This information is imparted through various forms including embryonic molecular and chemical substances, sound waves and electromagnetic waves.

Information gives origin to life and gives order to every single atom, molecule, and cell.

The work of Professor Pier Mario Biava

How did scientists come to these conclusions? This is where Professor Biava has made a significant and revolutionary contribution.

Professor Pier Mario Biava is a medical doctor based in Italy, specialising in occupational medicine and with a passion for research.

Very early in his career, Professor Biava become interested in environmental carcinogenesis (the study of the formation of cancer due to environmental effects). He was in his hometown, Trieste, Italy, a seaport with an established naval engineering industry which made substantial use of asbestos.

Different impact of carcinogens before and after embryonic period

Professor Biava noted that there were no systematic reports in Trieste of diseases linked to the asbestos, so he turned to the local hospitals.

Here he found 120 cases of undiagnosed cancer conditions. A particular finding from the medical reports struck him deeply; it was that the impact of carcinogens (substances that may increase the risk of cancer) was markedly different in the period during pregnancy compared to the period following pregnancy.

During pregnancy, the period in which organs form, carcinogens have no effect and cancer will not arise in the offspring. However, when the organogenesis (the period in which cells differentiate into organs) is over, carcinogens can, and do, produce tumours in the offspring.

The question arises as to why are there different impacts before and after pregnancy?

The impact of carcinogens was markedly different in the period during pregnancy compared to the period following pregnancy

As we saw above, the embryo goes through multiple stages of development. Immediately after fertilisation the egg cell divides from a single cell and billions of other similar cells, totipotent stem cells, will be generated.

All of these cells are identical, and it is only later that organs start taking form. For this to happen the cells need to specialise, that is differentiate.

In the second part of the development of the embryo, cells differentiate in three diverse types generating what is known as the germ layers - three types of cells: the ectoderm, the endoderm, and the mesoderm.

From these variations all the organs of tissues of the human body will originate. The multiplication and differentiation process will conclude with 252 different types of cells deriving from the germ layer, and each with a precise function.

All these cells will keep on multiplying until there are the billions necessary for developed life. During organogenesis different types of stem cell take form from a single totipotent stem cell.

Professor Biava realised that in the precise moment when these cells differentiate, the factors or substances responsible for this differentiation were able to prevent and correct all the damage inflicted by the carcinogens in the undifferentiated stem cells.

So, the question then arose as to whether tumours are similar to altered stem cells? Are they simply stem cells that have gone wrong?

If so, would it be possible to extract and use those substances responsible for the differentiation of the various types of stem cell, and administer them to tumours? In other words, can those defective cells be reset or reprogrammed?


DNA encodes all the instructions essential to the development and functioning of an organism.

Let’s examine differentiation in more detail. DNA encodes all the instructions essential to the development and functioning of an organism.

Every single cell contains the entire genetic code but not all of it is active. Depending on the type of cell and its function, some genes will turn on while others are turned off - in scientific terms they are expressed.


This turning on and off (activation and deactivation) of genes is how cells differentiate.

A neuron (a cell that fires electric signals, typically found in the brain) and a liver cell have the same DNA; what differentiates the neuron from the liver cell is only the formatting of the cell genes, i.e. by differences in the binary pattern of genes turned on and turned off.

DNA is used as a template to build RNA which is translated into peptides to control growth and differentiation and many other cell functions

The instruction for turning on and off single genes is known as the gene expression.

The epigenetic code is the “software” that controls and directs the DNA “hardware”

The gene expression is governed by a process that controls the direction of genes. This governing process is identified as epigenetics from the Greek - epi means over or above.

Epigenetics stands above genetics and the epigenetic code is the “software” that controls and directs the DNA “hardware” and thereby coordinates all the instructions organising life.

The “software” is made up of the proteins and chemical substances found in the embryo but also includes sound and electromagnetic waves.

Cancer cells are altered stem cells

From his review of reports at the Trieste hospitals, Professor Biava had an intuition that if all the factors of stem cell differentiation within the embryo are capable of blocking cancer growth, this should mean that cancer cells are altered stem cells and the key to further understanding lay in the research of embryonic factors.

Professor Biava began his research on epigenetics by studying the stages of differentiation of embryonic stem cells of zebra fish, a fish with a distinctive feature of having cells which are about 98% similar to human cells, and whose DNA had already been mapped.

Cancer is a reversible condition

Cancer cells are cells that multiply without control and differentiation and can be likened to out-of-control stem cells. It appears that something in the transmission of instructions within the cell breaks down and this leads to the development of a tumour and uncontrolled multiplication.

Was it possible to reprogram the cancer cells to differentiate exactly as occurs in stem cells? This question was answered by taking those differentiation substances, the epigenetic or controlling substances, from the zebra fish embryos and using these to treat diverse types of human cancer.

Cancer cells are cells that multiply without control and differentiation and can be likened to out-of-control stem cells

Experiments were made with seven diverse types of tumours. The treatment with the differentiation factors extracted from the zebra fish resulted in a very significant decline in the growth curves in all types of tumours.

This welcome decline was due to proteins blocking the cell cycle of the cancer cells and of doing one of two other things: (a) the repair of damage at the source of the malignancy followed by the cells going back to normal, and (b) if the damage was too serious, the genes controlling cell death activated and the cells died.

The important outcome is that these cells then came out of the multiplication circuit. Further studies showed that epigenetic substances extracted at distinct stages of embryonic development cycle and applied to cells led to different effects.

Extractions taken at later stages of the cycle showed positive impacts in the treatment of cancerous tumours. Earlier stage extractions were efficacious in the treatment of brain disease and ageing related issues and in skin care and repair.

The field of information

Professor Biava’s studies show that cancer diseases are caused by an abnormal flow of genetic epigenetic, and other information. Other studies have shown that the information can be transmitted through sound vibrations or, as explained by physics, through electromagnetic fields.

Environmental factors, diet and a healthy lifestyle are also relevant factors. We are beginning to see the formulation of a radical new way to look at life and human well-being.

A new medical paradigm is being born. Information is the foundation of our whole existence.

It is possible to discern the first steps to a marked shift in emphasis away from the traditional view that the human being is a mechanical series of organs interacting concurrently, and towards a concept of something deeply connected through the totality of cells.

Cells and organs now seem to be the product of something happening at a higher level, through an informational field permeating all of matter.

A new medical paradigm is being born. Information, albeit expressed through material factors, is the foundation of our whole existence.

It is what generates life and everything in the universe. It is information that underlies energy and matter. When this information is correct our lives work well and we are healthy; when this information is skewed, illness occurs.

Practical applications

Professor Biava’s work was centred around research into cancer, but the concept of cellular reprogramming is not limited to the treatment of cancer but applies to a range of diseases.

A great deal of work was also done on the development of the technology applied in extracting epigenetic factors from the zebra fish roe.

From this work, Novacell has developed the following supplements in the form of tablets and liquids which aid in the treatment of diseases as follows:

Cell Reprogram

Aids in cell repair and cell differentiation.

Cell Integrity Age

Aids in the prevention of chronic degenerative disease and slows down the phenomena of senescence.

Cell Integrity Brain

Aids in the good functioning of the cognitive function.

Synchro Levels

Has a balanced composition of substances that have been shown to improve the quality of life and overall conditions of patients with debilitating chronic diseases. It is useful both in prevention and in supporting people with reduced immune systems.

Royal Cells™ Day Cream

An innovative skin care product, based on cellular growth and differentiation factors, which support the metabolism of skin cells, contributing to the natural process of skin regeneration and renewal.

Royal Cells™ Night Cream

A nourishing and regenerating cream, based on cellular growth and differentiation factors, which support the metabolism of skin cells, contributing to the natural process of skin regeneration and renewal.

Royal Cells™ Radiance Serum

Regenerating and restructuring serum for the face, eye contour and neckline.

Royal Cells™ Lotion

Regenerating and restructuring lotion for sensitive, irritated, scalp. It is an anti-hair loss treatment, indicated in cases of progressive fall and thinning. Revitalizes and strengthens the hair.


Cells which cause cancer and other diseases can be made revert to their proper status by reprogramming

Cells are the basis of all life. A healthy body depends on properly functioning cells. Dysfunctional cells which cause cancer and other diseases can be made to revert to their proper status by reprogramming them using epigenetic substances.

The epigenetic coding does not change the structure of DNA but rather reconfigures the DNA mode in individual cells to be either active or inactive. The epigenetic code is the programme of life. Without this code life would not begin or be possible.

This summary is based on the documentary The Universe is a Dream, see video above, where Professor Biava and the philosopher Dr Ervin László discuss Professor Biava’s research and findings.

Professor Biava’s published scientific papers may be found on Pubmed: